Structure of PDB 8hw2 Chain A

Receptor sequence
>8hw2A (length=1375) Species: 9606 (Homo sapiens) [Search protein sequence]
FQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLW
CVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGV
QSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALV
LSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGY
RHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTAPRPRKPSFLKALL
ATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAG
LMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRAS
TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLA
GVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLY
AWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVY
VYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQ
FLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKG
ALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCT
LQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGG
QRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKT
RVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYIG
TVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMAD
SRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNK
IRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLV
VIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFS
ETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFV
GNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLES
NIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGL
DLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGL
NVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELS
HLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEA
TAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVA
EFDSPANLIAARGIFYGMARDAGLA
3D structure
PDB8hw2 Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
ChainA
Resolution3.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 7.6.2.-
7.6.2.2: ABC-type xenobiotic transporter.
7.6.2.3: ABC-type glutathione-S-conjugate transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U38 A Y371 F375 M584 Y1188 N1192 R1193 R1245 Y317 F321 M530 Y1036 N1040 R1041 R1093
BS02 U38 A W539 F1238 W1242 R1245 M1246 W485 F1086 W1090 R1093 M1094
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015164 glucuronoside transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015432 ABC-type bile acid transporter activity
GO:0016887 ATP hydrolysis activity
GO:0022857 transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity
GO:0071714 icosanoid transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006855 xenobiotic transmembrane transport
GO:0006869 lipid transport
GO:0015721 bile acid and bile salt transport
GO:0015779 glucuronoside transport
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
GO:0071716 leukotriene transport
GO:0098656 monoatomic anion transmembrane transport
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hw2, PDBe:8hw2, PDBj:8hw2
PDBsum8hw2
PubMed37485728
UniProtO15438|MRP3_HUMAN ATP-binding cassette sub-family C member 3 (Gene Name=ABCC3)

[Back to BioLiP]