Structure of PDB 8huo Chain A

Receptor sequence
>8huoA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKAFSKHIYNAYLKNFNMTKKKARSILTGKAAPFVIHDIETLWQAEKGL
VWLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLL
KYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKF
EFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALE
FHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPL
LQEIYKD
3D structure
PDB8huo Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor.
ChainA
Resolution2.671 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KKB A F246 R248 C249 T252 T253 H287 H413 M417 Y437 F64 R66 C67 T70 T71 H105 H231 M235 Y255
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8huo, PDBe:8huo, PDBj:8huo
PDBsum8huo
PubMed37627519
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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