Structure of PDB 8htg Chain A

Receptor sequence
>8htgA (length=332) Species: 10090 (Mus musculus) [Search protein sequence]
ATHRLLLLGAGESGKSTIVKQMRILHVNGFNPEKKQKILDIRKNVKDAIV
TIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLW
DDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLT
SGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYN
MVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAG
KSKIEDYFPEYANYTVPEDTPDAGEDPKVTRAKFFIRDLFLRISTATGDG
KHYCYPHFTCAVDTENIRRVFNDCRDIIQRMH
3D structure
PDB8htg Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.
ChainA
Resolution2.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S56 T191 S16 T150
BS02 GSP A G51 E52 S53 G54 K55 S56 T57 L185 R186 R188 T191 G213 N279 K280 D282 M283 C352 A353 V354 G11 E12 S13 G14 K15 S16 T17 L144 R145 R147 T150 G172 N238 K239 D241 M242 C310 A311 V312
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001975 response to amphetamine
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0031000 response to caffeine
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8htg, PDBe:8htg, PDBj:8htg
PDBsum8htg
PubMed38062020
UniProtQ8CGK7|GNAL_MOUSE Guanine nucleotide-binding protein G(olf) subunit alpha (Gene Name=Gnal)

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