Structure of PDB 8hr5 Chain A

Receptor sequence

>8hr5A (length=466) Species: 1542 (Clostridium novyi) [Search protein sequence]

MITVRKIKLTIMGDKDTRNSQYKWIRDEQYNQYRALNMGMTYLAVNDILY
MNESGLEIRTIKDLKDCEKDIDKNKKEIEKLKISLVENKIEDYKLKIVEL
NKILEETQKERMDIQKEFKEKYVDDLYQVLDKIPFKHLDNKSLVTQRIKA
DIKSDKSNGLLKGERSIRNYKRNFPLMTRGRDLKFKYDDNDDIEIKWMEG
IKFKVILGNRIKNSLELRHTLHKVIEGKYKICDSSLQFDKNNNLILNLTL
DIPIDIVNKKVSGRVVGVDLGLKIPAYCALNDYIKKSIGRIDDFLKVRTQ
MQSRRRRLQIAIQSAKGGKGRVNKLQALERFAEKEKNFAKTYNHFLSSNI
VKFAVSNQAEQINMELLSLKETQNKSILRNWSYYQLQTMIEYKAQREGIK
VKYIDPYHTSQTCSKCGNYEEGQRESQADFICKKCGYKVNADYNAARNIA
MSNKYITKKEESKYYK

3D structure

PDB

8hr5 Structure and engineering of miniature Clostridium novyi CRISPR-Cas12f1 with rare C-rich PAM specificity

Chain

Resolution

3.73 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	I2 V4 G13 D14 R188 R191 K194 F197 K227 G231 R233 I234 S237 L240 N348 T366 H369 F370 Y417 K418 R421	I2 V4 G13 D14 R165 R168 K171 F174 K204 G208 R210 I211 S214 L217 N323 T341 H344 F345 Y392 K393 R396
BS02	dna	A	S165 Q169 E360 S407 Y408 Y409	S142 Q146 E335 S382 Y383 Y384
BS03	dna	A	Y150 Q151 H160 L161 M221 E222	Y127 Q128 H137 L138 M198 E199

External links

PDB	RCSB:8hr5, PDBe:8hr5, PDBj:8hr5
PDBsum	8hr5
PubMed

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