Structure of PDB 8hr0 Chain A

Receptor sequence
>8hr0A (length=708) Species: 9606 (Homo sapiens) [Search protein sequence]
TYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLP
PIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGIS
ELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQ
MSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQE
MLGPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIA
VGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNA
KYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYM
VMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAIG
PCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVGRGAIQF
VTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAI
YRAETEDVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQFMFHL
RRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEP
VLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHL
LQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNDVSLQVFMDHL
KKLAVSSA
3D structure
PDB8hr0 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations
ChainA
Resolution3.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C61 C66 C85 C59 C64 C83
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0072659 protein localization to plasma membrane
GO:0090110 COPII-coated vesicle cargo loading
GO:0090114 COPII-coated vesicle budding
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030127 COPII vesicle coat
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0031410 cytoplasmic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070971 endoplasmic reticulum exit site

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hr0, PDBe:8hr0, PDBj:8hr0
PDBsum8hr0
PubMed
UniProtQ15436|SC23A_HUMAN Protein transport protein Sec23A (Gene Name=SEC23A)

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