Structure of PDB 8hoi Chain A

Receptor sequence
>8hoiA (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]
YDNREIVMKYIHYKLSQRGYEWSEVVHLTLRQAGDYFSRRYRRDFAEMSS
QLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMS
PLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP
3D structure
PDB8hoi Crystal structure of Bcl-2 D103Y in complex with sonrotoclax
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 98I A Y103 F104 Y108 D111 F112 M115 V133 W144 G145 R146 Y202 Y36 F37 Y41 D44 F45 M48 V66 W77 G78 R79 Y135
BS02 98I A Y103 L201 Y202 Y36 L134 Y135
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8hoi, PDBe:8hoi, PDBj:8hoi
PDBsum8hoi
PubMed38211332
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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