Structure of PDB 8ho5 Chain A

Receptor sequence
>8ho5A (length=1075) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
MEWIHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPL
DVEQAFAFYVKTLTHSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLH
THLNAYTFNDRTVYMAGSMNNKDFFNIMGVYMDSVFQPNVLENKYIFETE
GWTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIVYNEMKGALSSPLEDLYH
EEMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKKVKVFFFS
KNNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDH
SEEKENLVSVAWLLNPKVSDLSLENPTDYFVLLIINNLLIHTPESVLYKA
LTDCGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHYEVED
VIMNALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSK
LNYNRDPLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILL
EGDENYAQEQENLEKQELKKRIENFNEQEKEQVIKNFEELSKYKNAEESP
EHLNKFPIISISDLNKKTLEVPVNVYFTNINENNNIMETYNKLKTNEHML
KDNMDVFLKKYVLKKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELA
YLNLFKTLILENKTNKRSSEDFVILREKNIGSMSANVALYSKDDHLNVTD
KYNAQALFNLEMHVLSHKCNDALNIALEAVKESDFSNKKKVIDILKRKIN
GMKTTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQEQLELAEN
DFKTLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSY
FEENDKYIVMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKP
GEYLDPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARD
PNLEKTLATFRESAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELS
KLSFLRLISNESEQDRVEFRKRIMNTKKEDFYKFADLLESKVNEFEKNIV
IITTKEKANEYIANVDGEFKKVLIE
3D structure
PDB8ho5 Falcilysin in complex with MMV665806
ChainA
Resolution2.003 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XUN A L417 D451 A517 F527 E530 L333 D367 A433 F443 E446
BS02 ZN A H129 H133 E243 H72 H76 E186
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0042540 hemoglobin catabolic process
Cellular Component
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0020011 apicoplast
GO:0020020 food vacuole
GO:0031982 vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ho5, PDBe:8ho5, PDBj:8ho5
PDBsum8ho5
PubMed38593807
UniProtQ76NL8|FCLN_PLAF7 Falcilysin (Gene Name=FLN)

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