Structure of PDB 8ho1 Chain A

Receptor sequence
>8ho1A (length=392) Species: 1463854 (Streptomyces sp. NRRL F-5053) [Search protein sequence]
LTYPFHDWSQELSPRYAQLRASDAPVCPVVSEGTGDPLWLVTRYATAVKL
LEDSRFSSEAAQASGAPRQEPVELRAPGTRGDAIAMLREAGLRSVLADGL
GPRAVRRHQGWINDLAETLMSELASREGTFDLAADFVEPLSSALVSRTLL
GELSADERDLLAHCADTGLRFCGVTHEEQVHAFTQMHEFFLEHARRLAGT
PGEHLLKLIAEAPVPLSDEALAEAGSLLVVAGFPTSSGFLCGALLTLLRH
PDAVQELHAHPERVPSAVEELLRYTPLSTGSVKRMATEDLEIDGVRIKAG
EVVMVSLEAVNHDPDAFEDPDVFRPGREGPMHFGFGRGRHFCPGNRLARC
VIEATVRAVARRPGLRLAVAPEEISWHEGLGFRRPRAIPATW
3D structure
PDB8ho1 Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A L152 A237 G238 T241 F245 L283 V288 R290 G340 F341 H346 C348 P349 G350 L149 A231 G232 T235 F239 L277 V282 R284 G334 F335 H340 C342 P343 G344
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0036199 cholest-4-en-3-one 26-monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0006707 cholesterol catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ho1, PDBe:8ho1, PDBj:8ho1
PDBsum8ho1
PubMed37083030
UniProtA0A8I3B027

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