Structure of PDB 8hnw Chain A

Receptor sequence

>8hnwA (length=809) Species: 729 (Haemophilus parainfluenzae) [Search protein sequence]

ILGLDLGIASVGWAVVEIDEKENPLRLIDVGVRTFEGESLALSRRLARSA
RRLTQRRVARLKKAKRLLKSENILLSTDERLPHQVWQLRVEGLDHKLERQ
EWAAVLLHLIKHRGYLSQRKNESKELGALLSGVDNNHKLLQQATYRSPAE
LAVKKFEVEEGHIRNQQGAYTHTFSRLDLLAEMELLFSRQQHFGNPFASE
KLLENLTALLMWQKPALSGEAILKMLGKFEDEYKAAKNTYSAERFVWITK
LNNLRIQENGLERALNDNERLALMEQPYDKNRLFYSQVRSILKLSDIFKG
LRIETKAVLMEMKAYHQIRKVLEGNNLKAEWAELKANPTLLDEIGTAFSL
YKTDEDISAYLAGKLSQPVLNALLENLSFDKFIQLSLKALYKLLPLMQQG
LRYDEACREIYFLPQIPADEIRNPVVLRTLTQARKVINGVVRLYGSPARI
HIETRNLNDTRYVARFLCNFIADNMHLVFASNGQITALLNDRHHALDAVV
VACSTVAMQQKITRFLHFPTPWQFFKQEVEIRIFSDNPKLELENRLPDRP
QANHEFVQPLFVSRMPTRKMTGQGHMETVKSAKRLNEGISVIKMPLTKLK
LKDLELMVNREREKDLYDTLKARLEAFNDDPAKAFAEPFIKKGGAIVKSV
RVEQIQKSGVLVREGNGVADNASMVRVDVFTKGGKYFLVPIYTWQVAKGI
LPNKAATQYKDEEDWEVMDNSATFKFSLHPNDLVKLVTKKKTILGYFNGL
NRATGNIDIKEHDLDKSKGKQGIFEGVGIKLALSFEKYQVDELGKNIRLC
KPSKRQPVR

3D structure

PDB

8hnw AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.

Chain

Resolution

3.41 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	S54 R59 R60 A62 R63 R66 R67 L68 R71 K77 R81 H98 W101 H123 K126 R128 G129 Q133 L148 H181 I182 R183 N184 Q185 Q186 R195 K233 A235 K243 F266 I414 Q415 Y434 R466 N467 P468 L471 R472 T475 N661 R668 Q732 T735 R813 K814 M815 T816 G817 Q818 G819 H820 V824 K825 S826 K828 I837 K838 N854 R857 E858 K886 K887 G888 A890 I891 K893 S894 R896 R908 E909 N911 T938 W939 A942 K943 Q1034 E1037 C1045 R1054	S39 R44 R45 A47 R48 R51 R52 L53 R56 K62 R66 H83 W86 H108 K111 R113 G114 Q118 L129 H162 I163 R164 N165 Q166 Q167 R176 K214 A216 K224 F245 I383 Q384 Y403 R422 N423 P424 L427 R428 T431 N458 R465 Q510 T513 R568 K569 M570 T571 G572 Q573 G574 H575 V579 K580 S581 K583 I592 K593 N609 R612 E613 K641 K642 G643 A645 I646 K648 S649 R651 R663 E664 N666 T693 W694 A697 K698 Q789 E792 C800 R809
BS02	dna	A	Q133 R134 K135 G146 A147 L148 L149 Y189 L236 M244 L245 N274 R276 K383 D411 D435 R664 Y665 R668 Q732 M821 E822 T823 K847 Y954 N1001 G1021 V1022 G1023 I1024 K1025 L1026	Q118 R119 K120 G127 A128 L129 L130 Y170 L217 M225 L226 N253 R255 K352 D380 D404 R461 Y462 R465 Q510 M576 E577 T578 K602 Y709 N756 G776 V777 G778 I779 K780 L781
BS03	dna	A	S903 N916 A917 M919 Y937 N996 R997 A998	S658 N671 A672 M674 Y692 N751 R752 A753

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0043571	maintenance of CRISPR repeat elements
GO:0051607	defense response to virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8hnw, PDBe:8hnw, PDBj:8hnw
PDBsum	8hnw
PubMed	37494395
UniProt	F0ET08

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