Structure of PDB 8hni Chain A

Receptor sequence

>8hniA (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]

REKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGF
GFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKL
FVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHD
PVDKIVLQKYHTINGHNAEVRKALSRQEM

3D structure

PDB

8hni Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition.

Chain

Resolution

2.644 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E18 K22 F24 G26 G27 L28 S29 F30 D49 V51 M53 R62 G63 F64 F66 R89 A96 V97 R99 H108	E4 K8 F10 G12 G13 L14 S15 F16 D35 V37 M39 R48 G49 F50 F52 R75 A82 V83 R85 H94
BS02	dna	A	E18 Y174	E4 Y160
BS03	dna	A	K113 F115 G118 R153 F155 F157 R185 A187 L188 S189 R190 M193	K99 F101 G104 R139 F141 F143 R171 A173 L174 S175 R176 M179

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:8hni, PDBe:8hni, PDBj:8hni
PDBsum	8hni
PubMed	36528084
UniProt	P22626\|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (Gene Name=HNRNPA2B1)

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