Structure of PDB 8hnc Chain A

Receptor sequence
>8hncA (length=570) Species: 9606 (Homo sapiens) [Search protein sequence]
NGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFE
IGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYS
KSTLSTCLISPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLS
YIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLST
IRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNVTGFFQSFKS
ILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVI
TIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCE
NKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITY
ISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACT
RKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRA
LGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSM
LRVSSLVLYIILIYAMKKKY
3D structure
PDB8hnc Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
ChainA
Resolution3.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BLR A Y352 I353 F356 F386 Y271 I272 F275 F305
Gene Ontology
Molecular Function
GO:0008514 organic anion transmembrane transporter activity
GO:0015125 bile acid transmembrane transporter activity
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0015349 thyroid hormone transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006811 monoatomic ion transport
GO:0006869 lipid transport
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0015732 prostaglandin transport
GO:0042167 heme catabolic process
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport
GO:0070327 thyroid hormone transport
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hnc, PDBe:8hnc, PDBj:8hnc
PDBsum8hnc
PubMed37674011
UniProtQ9Y6L6|SO1B1_HUMAN Solute carrier organic anion transporter family member 1B1 (Gene Name=SLCO1B1)

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