Structure of PDB 8hlw Chain A

Receptor sequence
>8hlwA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSDLPYPEAI
FELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQN
IDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPR
CPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFAS
LTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGW
TEEMRDLVQRETGKLD
3D structure
PDB8hlw Identification of SIRT3 as an eraser of H4K16la.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H248 V292 F293 F294 G295 E296 L298 L322 E323 E325 H119 V163 F164 F165 G166 E167 L169 L193 E194 E196
BS02 ZN A C256 C259 C280 C127 C130 C151
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:8hlw, PDBe:8hlw, PDBj:8hlw
PDBsum8hlw
PubMed37720100
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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