Structure of PDB 8hlj Chain A

Receptor sequence
>8hljA (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
PESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGY
QSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSE
KIQLLEALGDIEIAIKLVKSERQGLEHPLDQHYRNLHCALRPLDHESYEF
KVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHG
SRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRL
KNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFV
TLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF
3D structure
PDB8hlj Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Olaparib (AZD2281)
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 09L A E335 H428 G429 R444 I445 G460 I461 Y462 F463 S470 Y473 E106 H199 G200 R215 I216 G231 I232 Y233 F234 S241 Y244
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8hlj, PDBe:8hlj, PDBj:8hlj
PDBsum8hlj
PubMed
UniProtQ9UGN5|PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (Gene Name=PARP2)

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