Structure of PDB 8hl7 Chain A

Receptor sequence
>8hl7A (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
MFVRVLEKRDGTVLRLQQYSSGGVGCVVWDAAIVLSKYLETPEFSALSRR
SVLELGSGTGAVGLMAATLGADVVVTDLEELQDLLKMNINMNKHLVTGSV
QAKVLKWGEEVPSPPDFILMADCIYYEESLEPLLKTLKDISGFETCIICC
YEQRTMGKNPEIEKKYFELLQLDFDFEKIPLEKHDEEYRSEDIHIIYIRK
3D structure
PDB8hl7 Structural basis for recognition and methylation of p97 by METTL21D, a valosin-containing protein lysine methyltransferase.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A G39 W43 A46 G75 G77 D96 L97 K125 W126 A143 D144 Y147 Y148 G25 W29 A32 G56 G58 D77 L78 K106 W107 A121 D122 Y125 Y126
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0051117 ATPase binding
Biological Process
GO:0006338 chromatin remodeling
GO:0018022 peptidyl-lysine methylation
GO:0018023 peptidyl-lysine trimethylation
GO:0032259 methylation
GO:0032780 negative regulation of ATP-dependent activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hl7, PDBe:8hl7, PDBj:8hl7
PDBsum8hl7
PubMed37456834
UniProtQ9H867|MT21D_HUMAN Protein N-lysine methyltransferase METTL21D (Gene Name=VCPKMT)

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