Structure of PDB 8hkq Chain A

Receptor sequence
>8hkqA (length=902) Species: 9606 (Homo sapiens) [Search protein sequence]
RSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSS
SEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFR
VSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRS
AMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTV
GYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKQTEKHVV
LCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLW
SQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRA
WAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPA
TSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREY
EGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYI
NITKEENSAFIFKQEEKRKIAPVLELAVEYVKGYPPNSPYIGSSPTLCHL
LPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIV
PLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSL
LQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITT
ELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRV
FSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWI
RTYGRLFQKLCSSSAEIPIGIYRTESHVFAAEWISQQRLSLYRRSERQEL
SELVKNRMKHLGLPTTGYDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDP
LA
3D structure
PDB8hkq Structural basis of human Slo2.2 channel gating and modulation.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LQ9 A C308 T311 F312 M334 L339 C193 T196 F197 M219 L224
BS02 ZN A C785 H787 C566 H568
BS03 NA A R780 L781 K783 Y790 Y796 R561 L562 K564 Y571 Y577
Gene Ontology
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8hkq, PDBe:8hkq, PDBj:8hkq
PDBsum8hkq
PubMed37494189
UniProtQ5JUK3|KCNT1_HUMAN Potassium channel subfamily T member 1 (Gene Name=KCNT1)

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