Structure of PDB 8hkp Chain A

Receptor sequence
>8hkpA (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
GEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQT
MFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQS
SRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVS
RPTEKTVFLVFMFAVSGICVVLNLAELNHLG
3D structure
PDB8hkp Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.
ChainA
Resolution3.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AV0 A Q16 H18 Q15 H17
Gene Ontology
Molecular Function
GO:0005243 gap junction channel activity
Biological Process
GO:0007154 cell communication
GO:0007267 cell-cell signaling
GO:0007268 chemical synaptic transmission
GO:0007601 visual perception
GO:0019228 neuronal action potential
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0005922 connexin complex
GO:0045202 synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hkp, PDBe:8hkp, PDBj:8hkp
PDBsum8hkp
PubMed36906653
UniProtQ9UKL4|CXD2_HUMAN Gap junction delta-2 protein (Gene Name=GJD2)

[Back to BioLiP]