Structure of PDB 8hke Chain A

Receptor sequence
>8hkeA (length=659) Species: 9606 (Homo sapiens) [Search protein sequence]
SVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDSSK
YSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDFGA
HRKRHRIGDPHFHQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFKTG
QTTKTLSNQKLTFVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITVPA
NESIYDRSVISDKTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIAPD
DSGCSTNTSRKSFNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLLFL
PIVINIIKNSRSLHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDEM
CFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGSHVFGTYE
CTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQW
FVRHESPSPAYTNILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGSI
CLAKERSLGSEKLKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCFI
INCIMYLMYYGCMKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTDW
TRSAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLIN
TRKTSINIF
3D structure
PDB8hke dsRNA transporter
ChainA
Resolution3.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R137 H166 R172 K294 N297 E298 K299 R104 H133 R139 K261 N264 E265 K266
BS02 rna A K43 K45 R135 H169 D171 Q174 K193 K10 K12 R102 H136 D138 Q141 K160
BS03 ZN A H540 D551 H740 H744 H423 D434 H623 H627
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8hke, PDBe:8hke, PDBj:8hke
PDBsum8hke
PubMed38664565
UniProtQ9GZC8|SID1_CAEEL Systemic RNA interference defective protein 1 (Gene Name=sid-1)

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