Structure of PDB 8hk7 Chain A

Receptor sequence
>8hk7A (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
KYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSK
TEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPDNRSFIFYENLLLGVPR
IRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTS
EKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFD
FFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVV
AIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVW
IKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMPFIIFLAYAQLAYLVFG
TQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFF
ILLNMFLAIINDTYSEVK
3D structure
PDB8hk7 Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AQV A A652 N653 R654 A432 N433 R434
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8hk7, PDBe:8hk7, PDBj:8hk7
PDBsum8hk7
PubMed38483987
UniProtQ13563|PKD2_HUMAN Polycystin-2 (Gene Name=PKD2)

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