Structure of PDB 8hje Chain A

Receptor sequence
>8hjeA (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
NPNDWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPSHT
EKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLDVSEFTHKLLDWLED
AFQLAVNVNSKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNG
YRNLDECLEGAMVQERWFTKLPPVLTFELSRFEFNQSQPEKIHNKLEFPQ
IIYMDRYMYGRQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQSWLKYNDI
SVTESSWEEVERDSYGGLRNVSAYCLMYINDKLFNMSEVEALSVELKHYI
QEDNWRFEQEVE
3D structure
PDB8hje Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VIS A L180 S257 T260 H261 L264 F292 Q315 T364 E366 L367 S368 Y643 C644 L31 S88 T91 H92 L95 F120 Q143 T176 E178 L179 S180 Y274 C275
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:8hje, PDBe:8hje, PDBj:8hje
PDBsum8hje
PubMed37075624
UniProtQ96RU2|UBP28_HUMAN Ubiquitin carboxyl-terminal hydrolase 28 (Gene Name=USP28)

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