Structure of PDB 8hir Chain A

Receptor sequence
>8hirA (length=918) Species: 9606 (Homo sapiens) [Search protein sequence]
RVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRV
LLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVA
IISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNL
FIPVFLNCWLAKHALENMINDFHRSAMFNQVLILFCTLLCLVFTGTCGIQ
HLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALV
VLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFL
NEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQ
DLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQ
ILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQ
EGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKK
YGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFVEYVK
GYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNK
LIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAIC
CFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKT
IVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERE
NGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTT
PGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHAAEWI
SQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYDHQNTLSYVLINPPPD
TRLEPSDIVYLIRSDPLA
3D structure
PDB8hir Structural basis of human Slo2.2 channel gating and modulation.
ChainA
Resolution3.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A L532 H535 S537 S557 G558 N559 E560 L442 H445 S447 S467 G468 N469 E470
BS02 ZN A C778 C785 H787 C577 C584 H586
Gene Ontology
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8hir, PDBe:8hir, PDBj:8hir
PDBsum8hir
PubMed37494189
UniProtQ5JUK3|KCNT1_HUMAN Potassium channel subfamily T member 1 (Gene Name=KCNT1)

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