Structure of PDB 8hik Chain A

Receptor sequence
>8hikA (length=498) Species: 562,9606 [Search protein sequence]
ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLED
KSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNA
YIQKYLSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNE
ITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVA
HMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTS
SVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNVLAR
MLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSAR
VYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLL
AHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVN
TFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAM
3D structure
PDB8hik Molecular mechanism of substrate recognition by folate transporter SLC19A1.
ChainA
Resolution3.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A E123 Y126 M130 R133 Y281 Y286 E206 Y209 M213 R216 Y328 Y333
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005542 folic acid binding
GO:0008514 organic anion transmembrane transporter activity
GO:0008517 folic acid transmembrane transporter activity
GO:0008518 folate:monoatomic anion antiporter activity
GO:0009055 electron transfer activity
GO:0015297 antiporter activity
GO:0015350 methotrexate transmembrane transporter activity
GO:0020037 heme binding
GO:0042910 xenobiotic transmembrane transporter activity
GO:0046872 metal ion binding
GO:0061507 2',3'-cyclic GMP-AMP binding
GO:0090482 vitamin transmembrane transporter activity
GO:0140360 cyclic-GMP-AMP transmembrane transporter activity
Biological Process
GO:0006855 xenobiotic transmembrane transport
GO:0007565 female pregnancy
GO:0015711 organic anion transport
GO:0015884 folic acid transport
GO:0022900 electron transport chain
GO:0046655 folic acid metabolic process
GO:0051180 vitamin transport
GO:0051958 methotrexate transport
GO:0071705 nitrogen compound transport
GO:0098656 monoatomic anion transmembrane transport
GO:0098838 folate transmembrane transport
GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane
GO:0141111 positive regulation of cGAS/STING signaling pathway
GO:0150104 transport across blood-brain barrier
GO:1904447 folate import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0042597 periplasmic space

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Molecular Function
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Cellular Component
External links
PDB RCSB:8hik, PDBe:8hik, PDBj:8hik
PDBsum8hik
PubMed36575193
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P41440|S19A1_HUMAN Reduced folate transporter (Gene Name=SLC19A1)

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