Structure of PDB 8hfv Chain A

Receptor sequence
>8hfvA (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVK
MAKDRRNHCGIASAASYPTV
3D structure
PDB8hfv Crystal structure of CTSL in complex with K777
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D137 H140 D137 H140
BS02 ZN A D71 D114 D71 D114
BS03 ZN A E50 E86 E50 E86
BS04 0IW A Q19 G23 C25 E63 N66 G67 G68 L69 A135 M161 D162 H163 W189 Q19 G23 C25 E63 N66 G67 G68 L69 A135 M161 D162 H163 W189
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8hfv, PDBe:8hfv, PDBj:8hfv
PDBsum8hfv
PubMed37990007
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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