Structure of PDB 8hfm Chain A

Receptor sequence
>8hfmA (length=404) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
MQSWSAPAIPVVPGRGPALRLFDSADRQVRPVTPGPTATMYVCGITPYDA
THLGHAATYLTFDLVHRLWLDAGHTVQYVQNVTDVDDDGIDWRTLGDRET
QLFREDMAALRVLPPHDYVAATDAIAEVVEMVEKLLASGAAYIVEDAEYP
DVYFRADATAQFGYESGYDRDTMLTLFAERGGDPDRPGKSDQLDALLWRA
ERPGEPSWPSPFGRGRPGWHVECSAIALTRIGTGLDIQGGGSDLIFPHHE
YSAAHAESVTGERRFARHYVHTGMIGWDGHKMSKSRGNLVLVSQLRAQGV
DPSAIRLGLFSGHYREDRFWSNEVLDEANARLARWRSATALPEAPDATDV
IARVRQYLADDLDTPKALAALDGWCTDALSYGGHDTESPRLVATTVDALL
GVDL
3D structure
PDB8hfm Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides.
ChainA
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.1.13: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C43 C231 H256 C43 C223 H248
Gene Ontology
Molecular Function
GO:0004817 cysteine-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0035446 cysteine-glucosaminylinositol ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006423 cysteinyl-tRNA aminoacylation
GO:0010125 mycothiol biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hfm, PDBe:8hfm, PDBj:8hfm
PDBsum8hfm
PubMed36499418
UniProtA0QZY0|MSHC_MYCS2 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (Gene Name=mshC)

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