Structure of PDB 8hf3 Chain A

Receptor sequence
>8hf3A (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
KVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECR
YLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEME
IEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSIC
DNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVAL
KSLKIGFLETLKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNE
DIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILP
3D structure
PDB8hf3 Cryo-EM structure of human ZDHHC9/GCP16 complex
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.225: protein S-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C141 C144 H154 C133 C136 H146
BS02 ZN A C155 C158 H168 C147 C150 H160
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016409 palmitoyltransferase activity
GO:0016746 acyltransferase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0043849 Ras palmitoyltransferase activity
Biological Process
GO:0000165 MAPK cascade
GO:0006612 protein targeting to membrane
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0018345 protein palmitoylation
GO:0044794 positive regulation by host of viral process
GO:0140639 positive regulation of pyroptotic inflammatory response
GO:0141111 positive regulation of cGAS/STING signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0002178 palmitoyltransferase complex
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hf3, PDBe:8hf3, PDBj:8hf3
PDBsum8hf3
PubMed38182928
UniProtQ9Y397|ZDHC9_HUMAN Palmitoyltransferase ZDHHC9 (Gene Name=ZDHHC9)

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