Structure of PDB 8hez Chain A

Receptor sequence
>8hezA (length=582) Species: 9606 (Homo sapiens) [Search protein sequence]
DNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGAS
LFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQAL
GWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAF
HEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPV
TGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYL
KLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLV
VKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAV
FVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAF
LCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEL
EDISEDPSWARVVNLNALLMMAVAVFLWGFYA
3D structure
PDB8hez Structural basis of glucose transport by the human SGLT2-MAP17 glucose transporter
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L658 M661 A662 V665 F666 G669 F670 L568 M571 A572 V575 F576 G579 F580
BS02 LE6 A N75 G79 H80 G83 L84 T87 F98 E99 V286 S287 W291 K321 F453 Q457 N55 G59 H60 G63 L64 T67 F78 E79 V266 S267 W271 K301 F433 Q437
BS03 NA A A73 I76 G77 A389 S392 S393 A53 I56 G57 A369 S372 S373
Gene Ontology
Molecular Function
GO:0005362 low-affinity D-glucose:sodium symporter activity
GO:0005412 D-glucose:sodium symporter activity
GO:0005515 protein binding
GO:0015151 alpha-glucoside transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0022857 transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0000017 alpha-glucoside transport
GO:0005975 carbohydrate metabolic process
GO:0006814 sodium ion transport
GO:0008645 hexose transmembrane transport
GO:0035623 renal D-glucose absorption
GO:0055085 transmembrane transport
GO:0098708 D-glucose import across plasma membrane
GO:0098719 sodium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hez, PDBe:8hez, PDBj:8hez
PDBsum8hez
PubMed38057552
UniProtP31639|SC5A2_HUMAN Sodium/glucose cotransporter 2 (Gene Name=SLC5A2)

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