Structure of PDB 8hei Chain A

Receptor sequence
>8heiA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAH
VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVG
CRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGH
AIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPRTD
3D structure
PDB8hei Crystal structure of CTSB in complex with E64d
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.1: cathepsin B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E6D A Q23 G27 C29 W30 G73 G74 A173 G198 H199 E245 Q24 G28 C30 W31 G74 G75 A174 G199 H200 E246
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8hei, PDBe:8hei, PDBj:8hei
PDBsum8hei
PubMed37990007
UniProtP07858|CATB_HUMAN Cathepsin B (Gene Name=CTSB)

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