Structure of PDB 8hcg Chain A

Receptor sequence
>8hcgA (length=219) Species: 10090 (Mus musculus) [Search protein sequence]
MQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSQGHPPPVPRPPR
VVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFL
QRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKAL
EQASSPSGKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALL
QWVDEHARPFSTVKPMYGT
3D structure
PDB8hcg Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids.
ChainA
Resolution1.799 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D5M A E20 A21 L24 A81 I84 Y129 H195 E10 A11 L14 A69 I72 Y117 H179
BS02 MG A D18 E20 D200 D8 E10 D184
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:8hcg, PDBe:8hcg, PDBj:8hcg
PDBsum8hcg
PubMed37870446
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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