Structure of PDB 8hcc Chain A

Receptor sequence
>8hccA (length=229) Species: 10090 (Mus musculus) [Search protein sequence]
QTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGH
PPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDN
LAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCV
DSIAALKALEQASSPSGSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLL
SICQWKPQALLQWVDEHARPFSTVKPMYG
3D structure
PDB8hcc Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A D18 L19 E20 A21 G23 I84 Y129 H195 D15 L16 E17 A18 G20 I81 Y126 H190
BS02 MG A D18 E20 D200 D15 E17 D195
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:8hcc, PDBe:8hcc, PDBj:8hcc
PDBsum8hcc
PubMed37870446
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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