Structure of PDB 8h8r Chain A

Receptor sequence

>8h8rA (length=513) Species: 9913 (Bos taurus) [Search protein sequence]

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGD
DQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNM
SFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSL
HLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLP
VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPG
FGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTV
GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLF
SGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMW
NTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPP
PYHTFEEPTYVNL

3D structure

PDB

8h8r Calcium-bound structure of bovine cytochrome c oxidase.

Chain

Resolution

1.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEA	A	G27 T31 S34 R38 Y54 V58 H61 A62 M65 I73 G125 W126 Y371 F377 H378 L381 S382 V386 F393 M417 F425 R438 R439 V465 M468	G27 T31 S34 R38 Y54 V58 H61 A62 M65 I73 G125 W126 Y371 F377 H378 L381 S382 V386 F393 M417 F425 R438 R439 V465 M468
BS02	HEA	A	W126 W236 V243 Y244 H290 H291 T309 G317 G352 G355 I356 L358 A359 D364 H368 V373 H376 F377 V380 L381 R438	W126 W236 V243 Y244 H290 H291 T309 G317 G352 G355 I356 L358 A359 D364 H368 V373 H376 F377 V380 L381 R438
BS03	CU	A	H240 H290 H291	H240 H290 H291
BS04	MG	A	H368 D369	H368 D369
BS05	CA	A	E40 Q43 G45	E40 Q43 G45
BS06	DMU	A	N406 T408 W409 R480	N406 T408 W409 R480
BS07	DMU	A	S307 I311	S307 I311
BS08	DMU	A	W334 K411 F418	W334 K411 F418

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0045277	respiratory chain complex IV

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8h8r, PDBe:8h8r, PDBj:8h8r
PDBsum	8h8r
PubMed	36708913
UniProt	P00396\|COX1_BOVIN Cytochrome c oxidase subunit 1 (Gene Name=MT-CO1)

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