Structure of PDB 8h7b Chain A

Receptor sequence
>8h7bA (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
SDELYRQSLEIISRYLREQATGAKDTKPMGRGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB8h7b 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.
ChainA
Resolution1.46408 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QHR A H224 A227 F228 M231 K234 M250 V253 F254 R263 T266 L267 F270 G271 I294 H53 A56 F57 M60 K63 M79 V82 F83 R92 T95 L96 F99 G100 I123
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8h7b, PDBe:8h7b, PDBj:8h7b
PDBsum8h7b
PubMed36774655
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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