Structure of PDB 8h6c Chain A

Receptor sequence
>8h6cA (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
GIIEFHVIGNSANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKT
LALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKE
YHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATL
MECELNPRIPYT
3D structure
PDB8h6c Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MLC A C579 A580 V581 Q586 V587 G589 G591 T592 A618 G620 Y621 K624 C79 A80 V81 Q86 V87 G89 G91 T92 A118 G120 Y121 K124
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:8h6c, PDBe:8h6c, PDBj:8h6c
PDBsum8h6c
PubMed37040526
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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