Structure of PDB 8h69 Chain A

Receptor sequence

>8h69A (length=716) Species: 93838 (Influenza A virus (A/goose/Guangdong/1/1996(H5N1))) [Search protein sequence]

MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD
FHFIDERGESTIIESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGV
EKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEKTHIHIFSF
TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEET
IEERFEITGTMCRLADQSLPPNFSSLEKFRAYVDGFEPNGCIEGKLSQMS
KEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIEN
EEKIPKTKNMRKTSQLKWALGENMAPEKVDFEDCKDVSDLRQYDSDEPKP
RSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV
SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL
YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL
RTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGMEEGSIGKVCRTLLAKSVFNSLY
ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV
LLNASWFNSFLTHALK

3D structure

PDB

8h69 An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles.

Chain

Resolution

3.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	M477 H510 L511 R512 K572	M477 H510 L511 R512 K572
BS02	rna	A	H326 K328 G371 N373 M374 A375 P376 K378 Y393 D394 S395 E397 P398 R508 H510 R512 D516 V517 N519 K539 R566 T567 N568 G569 P653 N696	H326 K328 G371 N373 M374 A375 P376 K378 Y393 D394 S395 E397 P398 R508 H510 R512 D516 V517 N519 K539 R566 T567 N568 G569 P653 N696

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006351	DNA-templated transcription
GO:0039523	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694	viral RNA genome replication
GO:0075523	viral translational frameshifting
GO:0075526	cap snatching

	Cellular Component
GO:0030430	host cell cytoplasm
GO:0042025	host cell nucleus

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8h69, PDBe:8h69, PDBj:8h69
PDBsum	8h69
PubMed	37488357
UniProt	Q9Q0U9\|PA_I96A0 Polymerase acidic protein (Gene Name=PA)

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