Structure of PDB 8h4r Chain A

Receptor sequence
>8h4rA (length=287) Species: 6182,9606 [Search protein sequence]
DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIRE
ISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPL
HLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARA
FGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKA
LFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEI
VPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS
3D structure
PDB8h4r The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus
ChainA
Resolution2.75 Å
3D
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Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
2.7.11.22: cyclin-dependent kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1QK A I10 A31 F80 L83 S84 Q85 D86 L134 I9 A30 F79 L82 S83 Q84 D85 L133
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0030332 cyclin binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0006749 glutathione metabolic process
GO:0006974 DNA damage response
GO:0007165 signal transduction
GO:0008283 cell population proliferation
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010468 regulation of gene expression
GO:0016310 phosphorylation
GO:0045023 G0 to G1 transition
GO:0045746 negative regulation of Notch signaling pathway
GO:0051301 cell division
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h4r, PDBe:8h4r, PDBj:8h4r
PDBsum8h4r
PubMed
UniProtP08515|GST26_SCHJA Glutathione S-transferase class-mu 26 kDa isozyme;
Q00526

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