Structure of PDB 8h0z Chain A

Receptor sequence
>8h0zA (length=1022) Species: 2901879 (Severe acute respiratory syndrome coronavirus) [Search protein sequence]
TQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHNPVIPFKDGI
YFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPF
FTMIFDNAFNCTFEYISDAFKHLREFVFKNKDGFLYVYKGYQPIDVVRDL
PSGFNTLKPIFKLPLGINITNFRAILTAAAAYFVGYLKPTTFMLKYDENG
TITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNIT
NLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVC
ATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCV
LAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPP
ALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLI
KNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEI
LDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTWRIYSTGNNVFQTQAG
CLIGAEHVDTSYECDIPIGAGICASYHTQKSIVAYTMSLGADSSIAYSNN
TIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFC
TQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPL
KPTKRSFIEDLLFNKVTLGFMKQYGECRDLICAQKFNGLTVLPPLLTDDM
IAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
QKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSN
FGAISSVLNDILSRLCKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIR
ASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVP
SQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDN
TFVSGNCDVVIGIINNTVYDPL
3D structure
PDB8h0z Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
ChainA
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EIC A C323 V328 Y352 F364 F379 C253 V258 Y282 F294 F309
BS02 BLA A V98 W101 N118 R183 K198 Y200 V61 W64 N81 R124 K139 Y141
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039587 suppression by virus of host tetherin activity
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046598 positive regulation of viral entry into host cell
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0052170 symbiont-mediated suppression of host innate immune response
GO:0061025 membrane fusion
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h0z, PDBe:8h0z, PDBj:8h0z
PDBsum8h0z
PubMed37402591
UniProtP59594|SPIKE_SARS Spike glycoprotein (Gene Name=S)

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