Structure of PDB 8h0y Chain A

Receptor sequence
>8h0yA (length=1044) Species: 2901879 (Severe acute respiratory syndrome coronavirus) [Search protein sequence]
TQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTNPVIPFKDG
IYFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNP
FFAMIFDNAFNCTFEYISDAFKHLREFVFKNKDGFLYVYKGYQPIDVVRD
LPSGFNTLKPIFKLPLGINITNFRAILTAAAAYFVGYLKPTTFMLKYDEN
GTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNI
TNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGV
CATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGC
VLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTP
PALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDL
IKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSE
ILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAW
RIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTQKSIVAY
TMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGD
STECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLK
YFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLAGFMKQYGECLGDINAR
DLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIP
FAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGK
LQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLCKVEAEVQIDRLI
TGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGY
HLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVF
NGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPL
3D structure
PDB8h0y Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EIC A C323 P324 F364 F379 C254 P255 F295 F310
BS02 BLA A V98 W101 N118 V123 F185 K198 V62 W65 N82 V87 F127 K140
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039587 suppression by virus of host tetherin activity
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046598 positive regulation of viral entry into host cell
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0052170 symbiont-mediated suppression of host innate immune response
GO:0061025 membrane fusion
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h0y, PDBe:8h0y, PDBj:8h0y
PDBsum8h0y
PubMed37402591
UniProtP59594|SPIKE_SARS Spike glycoprotein (Gene Name=S)

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