Structure of PDB 8h0j Chain A

Receptor sequence
>8h0jA (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
QVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQE
ISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKG
AGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRM
LVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRS
VSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLA
ETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKG
DTSGDYKKALLLLCGEDDC
3D structure
PDB8h0j structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A M28 G30 L31 G32 E72 M26 G28 L29 G30 E70
BS02 CA A G32 T33 G30 T31
BS03 CA A K70 L73 T74 E78 K68 L71 T72 E76
BS04 CA A A258 G263 A256 G261
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0043066 negative regulation of apoptotic process
GO:0050819 negative regulation of coagulation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0042383 sarcolemma
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072563 endothelial microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h0j, PDBe:8h0j, PDBj:8h0j
PDBsum8h0j
PubMed
UniProtP08758|ANXA5_HUMAN Annexin A5 (Gene Name=ANXA5)

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