Structure of PDB 8gxp Chain A

Receptor sequence
>8gxpA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQGASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGY
QRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAM
EVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLS
ALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTH
RQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSG
GKILHRLLQ
3D structure
PDB8gxp Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR gamma antagonists.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 06L A W317 C320 A321 H323 V376 F377 L396 I400 H479 Y502 W59 C62 A63 H65 V118 F119 L138 I142 H221 Y244
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gxp, PDBe:8gxp, PDBj:8gxp
PDBsum8gxp
PubMed37236000
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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