Structure of PDB 8gx3 Chain A

Receptor sequence
>8gx3A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
ENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTY
GIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLL
HRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSA
EGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAP
SDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQ
VNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMED
GEFWMSFRDFMREFTRLEICNLTPDAL
3D structure
PDB8gx3 The crystal structure of human Calpain-1 protease core in complex with 14c
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.52: calpain-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KJ0 A Q109 G113 C115 G207 G208 S251 M260 E261 G271 H272 W298 Q78 G82 C84 G176 G177 S220 M229 E230 G240 H241 W267
BS02 CA A V99 G101 D106 E182 E185 V68 G70 D75 E151 E154
BS03 CA A E302 D309 M329 D331 E333 E271 D278 M298 D300 E302
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0008284 positive regulation of cell population proliferation
GO:0016241 regulation of macroautophagy
GO:0032801 receptor catabolic process
GO:0050790 regulation of catalytic activity
GO:0060056 mammary gland involution
GO:0097264 self proteolysis
GO:0098989 NMDA selective glutamate receptor signaling pathway
Cellular Component
GO:0001533 cornified envelope
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0110158 calpain complex
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gx3, PDBe:8gx3, PDBj:8gx3
PDBsum8gx3
PubMed
UniProtP07384|CAN1_HUMAN Calpain-1 catalytic subunit (Gene Name=CAPN1)

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