Structure of PDB 8gvw Chain A

Receptor sequence

>8gvwA (length=671) Species: 9606 (Homo sapiens)

RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECV
SSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSK
VENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDLAKLKVAI
KYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPML
SIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQDLHVQGPP
PTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLAT
ISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTA
NSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDE
PNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMS
YFDEGGTLPPPFNIISLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTE
ENFKELKQDISSFRYEVLDLL

3D structure

• PDB: 8gvw Molecular architecture of the G alpha i -bound TRPC5 ion channel.
• Chain: A
• Resolution: 3.59 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	A	Y316 F497 N500	Y272 F448 N451
BS02	ZN	A	H172 C178 C181	H140 C146 C149
BS03	CA	A	E418 E421 N436 D439	E369 E372 N387 D390
BS04	YZY	A	Y524 Q573 F576	Y475 Q524 F527
BS05	YZY	A	F599 T603 V610 I611	F550 T554 V561 I562

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8gvw, PDBe:8gvw, PDBj:8gvw
• PDBsum: 8gvw
• PubMed: 37137991
• UniProt: Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)