Structure of PDB 8gvm Chain A

Receptor sequence

>8gvmA (length=514) Species: 9913 (Bos taurus) [Search protein sequence]

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGD
DQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNM
SFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSL
HLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLP
VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPG
FGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTV
GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLF
SGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMW
NTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPP
PYHTFEEPTYVNLK

3D structure

PDB

8gvm X-ray structural analyses of azide-bound cytochromecoxidases reveal that the H-pathway is critically important for the proton-pumping activity

Chain

Resolution

1.851 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEA	A	A24 G27 T31 S34 I37 R38 Y54 V58 H61 A62 M65 M69 I73 G125 W126 Y371 F377 H378 L381 S382 V386 F393 M417 F425 R438 R439 M468	A24 G27 T31 S34 I37 R38 Y54 V58 H61 A62 M65 M69 I73 G125 W126 Y371 F377 H378 L381 S382 V386 F393 M417 F425 R438 R439 M468
BS02	HEA	A	W126 W236 V243 Y244 H290 T316 G317 G352 G355 L358 D364 H368 V373 H376 F377 V380 L381 R438	W126 W236 V243 Y244 H290 T316 G317 G352 G355 L358 D364 H368 V373 H376 F377 V380 L381 R438
BS03	CU	A	H240 H290 H291	H240 H290 H291
BS04	MG	A	H368 D369	H368 D369
BS05	AZI	A	H240 V243 H291	H240 V243 H291
BS06	AZI	A	H240 H290	H240 H290

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0045277	respiratory chain complex IV

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8gvm, PDBe:8gvm, PDBj:8gvm
PDBsum	8gvm
PubMed	30077971
UniProt	P00396\|COX1_BOVIN Cytochrome c oxidase subunit 1 (Gene Name=MT-CO1)

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