Structure of PDB 8guw Chain A

Receptor sequence
>8guwA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
GEDFRSGSEAFDLIAQDEEEFNKSKKRQWALEDFEIGRPLGKGKFGNVYL
AREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGY
FHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS
KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSGTLDYLPPEMIEGRMH
DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGA
RDLISRLLKHNPSQRPMLREVLEHPWITANSS
3D structure
PDB8guw Structural basis for CEP192-mediated regulation of centrosomal AURKA.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A L139 G140 K162 Y212 A213 L263 L40 G41 K63 Y113 A114 L164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8guw, PDBe:8guw, PDBj:8guw
PDBsum8guw
PubMed37083534
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA);
Q8TEP8

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