Structure of PDB 8gu6 Chain A

Receptor sequence
>8gu6A (length=1211) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence]
MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGRTAGKSF
ITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSFLRK
RHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFSNFD
LDHDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGTYTGRITLR
NEHAKKLLLASLGFVDKLCGALCRIEVIHNDELRKQAEVIVEAFKQNDKL
EKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDIKVQGTALR
TKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETGGTEYYSSDLFIPVTP
PEGIETKEWIIVGRLKAATPFYFGVQQPSDSIPGEHTSFNILLDKENRYR
IPRSALRGALRRDLRTAFGSGCNVSLGGQILCNCKVCIEMRRITLKDSVS
DFSEPPEIRYRIAKNPGTATVEDGSLFDIEVGPEGLTFPFVLRYRGHKFP
EQLSSVIRYWEENDGKNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQKIN
EYIKERGMRGKEKELLEMLPDGLIPYKFFEERECLFPYKENLKPQWSEVQ
YTIEVGSPLLTADTISALTEPGNRDAIAYKKRVYNDGNNAIEPEPRFAVK
SETHRGIFRTAVGRRTGDLGKEDHEDCTCDMCIIFGNEHESSKIRFEDLE
LINGNEFEKLEKHIDHVAIDRFTGGALDKAKFDTYPLAGSPKKPLKLKGR
FWIKKGFSGDHKLLITTALSDIRDGLYPLGSKGGVGYGWVAGISIDDNVP
DDFKEMINKINNDYVHPGHQSPKQDNIYYPHYFLDSGSKVYREKDIITHE
EFTEELLSGKINCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKFFNIN
GELMIPGSELRGMLRTHFEALTKSCFAIFGEDSTKTLGGKLDKALHPCTG
LSDGLCPGCHLFGTTDYKGRVKFGFAKYENGPEWLITRGNNPERSLTLGV
LESPRPAFSIPDDESEIPGRKFYLHHNGWRIIRQKQLEIRETVQPERNVT
TEVMDKGNVFSFDVRFENLREWELGLLLQSLDPGKNIAHKLGKGKPYGFG
SVKIKIDSLHTFKIKRVPQSDIREYINKGYQKLIEWLPQWHVIPHIDKLY
KLLWVPFLLEPDVRYPVLNEESKGYIEGSDYTYKKLGDKDNLPYKTRVKG
LTTPWSPWNPF
3D structure
PDB8gu6 Target RNA-guided protease activity in type III-E CRISPR-Cas system.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A E16 W23 R37 Q39 F41 T45 K47 K55 F57 G60 T61 L62 R64 S65 S91 F92 Q93 T94 K101 P102 S103 F104 L105 R106 K107 R108 L133 G134 R135 G140 K141 E144 Y149 H152 F153 N155 D157 R176 I177 L178 N179 R180 V181 G186 D190 Y191 F192 G232 Y389 S391 D400 R472 S473 A474 R476 G477 R481 S494 L495 G496 G497 L500 R510 T513 L514 Y529 R530 I531 A532 K533 T539 L545 F546 G593 L594 D595 S596 T684 A685 K723 E725 T726 R728 G729 I730 R732 T733 N760 E763 S765 D788 H789 V790 A791 I792 R794 F805 S854 K855 Y922 P967 T969 S1001 E1002 R1004 R1008 G1421 T1422 T1423 Y1425 K1426 V1458 L1459 E1460 S1461 P1462 R1463 F1466 K1479 Y1481 G1550 K1551 G1552 K1553 P1554 Y1645 L1648 Y1663 E11 W18 R32 Q34 F36 T40 K42 K48 F50 G53 T54 L55 R57 S58 S84 F85 Q86 T87 K94 P95 S96 F97 L98 R99 K100 R101 L126 G127 R128 G133 K134 E137 Y142 H145 F146 N148 D150 R164 I165 L166 N167 R168 V169 G174 D178 Y179 F180 G220 Y339 S341 D343 R403 S404 A405 R407 G408 R412 S425 L426 G427 G428 L431 R441 T444 L445 Y460 R461 I462 A463 K464 T470 L476 F477 G524 L525 D526 S527 T611 A612 K650 E652 T653 R655 G656 I657 R659 T660 N687 E690 S692 D715 H716 V717 A718 I719 R721 F732 S781 K782 Y829 P874 T876 S908 E909 R911 R915 G963 T964 T965 Y967 K968 V1000 L1001 E1002 S1003 P1004 R1005 F1008 K1021 Y1023 G1092 K1093 G1094 K1095 P1096 Y1165 L1168 Y1183
BS02 rna A K187 A188 K189 R294 I295 K320 E322 R323 H328 Y367 K371 S457 F458 V540 E541 D542 G543 L545 F546 D698 E761 D801 K802 A803 K804 F805 K985 T1423 L1459 S1461 Q1502 R1505 L1648 K175 A176 K177 R254 I255 K280 E282 R283 H288 Y327 K331 S388 F389 V471 E472 D473 G474 L476 F477 D625 E688 D728 K729 A730 K731 F732 K892 T965 L1001 S1003 Q1044 R1047 L1168
BS03 ZN A C491 C501 C503 C506 C422 C432 C434 C437
BS04 ZN A C88 C121 C130 C81 C114 C123
BS05 ZN A H747 C750 C752 C755 H674 C677 C679 C682
BS06 ZN A C1018 C1414 C1417 C925 C956 C959
Gene Ontology
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8gu6, PDBe:8gu6, PDBj:8gu6
PDBsum8gu6
PubMed36484100
UniProtA0A0B0EGF3

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