Structure of PDB 8gtg Chain A

Receptor sequence
>8gtgA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
MEILNEEKKSKVHYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRN
IIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTN
FFWMFGEGCYLHTAIVLTDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDN
EKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSE
TIQARKAVKATLVLLPLLGITYMLAFVNPGEDEVSRVVFIYFNAFLESFQ
GFFVSVFACFLNS
3D structure
PDB8gtg Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CW9 A F162 F203 M206 L280 N283 F284 L320 L323 F60 F101 M104 L175 N178 F179 L215 L218
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gtg, PDBe:8gtg, PDBj:8gtg
PDBsum8gtg
PubMed37653040
UniProtP34998|CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (Gene Name=CRHR1)

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