Structure of PDB 8gt5 Chain A

Receptor sequence
>8gt5A (length=362) Species: 9606 (Homo sapiens) [Search protein sequence]
TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQDSYVGDEAQSKRG
ILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPK
ANREKMTQIMFETFNVPAMYVAIAAVLSLYASGRTTGIVLDSGDGVTHNV
PIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIK
EKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQ
PSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRM
QKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYD
EAGPSIVHRKCF
3D structure
PDB8gt5 Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G13 S14 G15 L16 K18 G156 D157 G182 R210 K213 E214 G301 G302 M305 Y306 K336 G9 S10 G11 L12 K14 G143 D144 G169 R197 K200 E201 G288 G289 M292 Y293 K323
Gene Ontology
Molecular Function
GO:0000146 microfilament motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017022 myosin binding
Biological Process
GO:0007015 actin filament organization
GO:0010628 positive regulation of gene expression
GO:0030048 actin filament-based movement
GO:0030240 skeletal muscle thin filament assembly
GO:0031032 actomyosin structure organization
GO:0033275 actin-myosin filament sliding
GO:0043066 negative regulation of apoptotic process
GO:0055003 cardiac myofibril assembly
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060047 heart contraction
GO:0070252 actin-mediated cell contraction
GO:0090131 mesenchyme migration
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030017 sarcomere
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031674 I band
GO:0044297 cell body
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gt5, PDBe:8gt5, PDBj:8gt5
PDBsum8gt5
PubMed37009486
UniProtP68032|ACTC_HUMAN Actin, alpha cardiac muscle 1 (Gene Name=ACTC1)

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