Structure of PDB 8gr9 Chain A

Receptor sequence
>8gr9A (length=432) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EKTLKERFSEIYPIHAQDVRQFVKEHGKTKISDVLLEQVYGGMRGIPGSV
WEGSVLDPEDGIRFRGRTIADIQKDLPKAKGSSQPLPEALFWLLLTGEVP
TQAQVENLSADLMSRSELPSHVVQLLDNLPKDLHPMAQFSIAVTALESES
KFAKAYAQGISKQDYWSYTFEDSLDLLGKLPVIAAKIYRNVFKDGKMGEV
DPNADYAKNLVNLIGSKDEDFVDLMRLYLTIHSDHEGGNVSAHTSHLVGS
ALSSPYLSLASGLNGLAGPLHGRANQEVLEWLFALKEESKDTIEKYLWDT
LNSGRVIPGYGHAVLRKTDPRYMAQRKFAMDHFPDYELFKLVSSIYEVAP
GVLTEHGKTKNPWPNVDAHSGVLLQYYGLKESSFYTVLFGVSRAFGILAQ
LITDRAIGASIERPKSYSTEKYKELVKNIESK
3D structure
PDB8gr9 Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress.
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A R66 L292 A296 V333 I334 G336 Y337 G338 H339 A340 K385 T386 K387 N392 R44 L270 A274 V306 I307 G309 Y310 G311 H312 A313 K358 T359 K360 N365
BS02 OAA A H257 N261 H293 H339 R348 R420 H235 N239 H271 H312 R321 R393
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0042802 identical protein binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gr9, PDBe:8gr9, PDBj:8gr9
PDBsum8gr9
PubMed37058555
UniProtP08679|CISY2_YEAST Citrate synthase, peroxisomal (Gene Name=CIT2)

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