Structure of PDB 8goe Chain A

Receptor sequence
>8goeA (length=407) Species: 9606 (Homo sapiens) [Search protein sequence]
DPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEI
TPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAH
MQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSS
VLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDSV
LARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLV
FLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVF
GVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGA
MLDGLRH
3D structure
PDB8goe Recognition of cyclic dinucleotides and folates by human SLC19A1.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 THH A T49 L72 E123 Y126 M130 R133 Y281 Y282 V285 Y286 T31 L54 E105 Y108 M112 R115 Y231 Y232 V235 Y236
Gene Ontology
Molecular Function
GO:0008518 folate:monoatomic anion antiporter activity
GO:0015350 methotrexate transmembrane transporter activity
GO:0090482 vitamin transmembrane transporter activity
Biological Process
GO:0015884 folic acid transport
GO:0051180 vitamin transport
GO:0051958 methotrexate transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8goe, PDBe:8goe, PDBj:8goe
PDBsum8goe
PubMed36265513
UniProtP41440|S19A1_HUMAN Reduced folate transporter (Gene Name=SLC19A1)

[Back to BioLiP]