Structure of PDB 8gmd Chain A

Receptor sequence
>8gmdA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
YIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHD
LQVCKREIQIMRDLGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQV
VNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILL
HDGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS
GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQD
MHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPI
3D structure
PDB8gmd Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZRR A E54 A58 V60 K74 M126 F128 C129 E180 L183 D194 E21 A25 V27 K41 M92 F94 C95 E146 L149 D159
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8gmd, PDBe:8gmd, PDBj:8gmd
PDBsum8gmd
PubMed37362320
UniProtQ2M2I8|AAK1_HUMAN AP2-associated protein kinase 1 (Gene Name=AAK1)

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