Structure of PDB 8gmc Chain A

Receptor sequence
>8gmcA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
YIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHD
LQVCKREIQIMRGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVN
LMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHR
GHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
IITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMH
CLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIP
3D structure
PDB8gmc Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YFV A L52 A53 E54 A58 V60 A72 K74 M126 F128 C129 Q133 E180 L183 D194 L19 A20 E21 A25 V27 A39 K41 M90 F92 C93 Q97 E144 L147 D157
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8gmc, PDBe:8gmc, PDBj:8gmc
PDBsum8gmc
PubMed37362320
UniProtQ2M2I8|AAK1_HUMAN AP2-associated protein kinase 1 (Gene Name=AAK1)

[Back to BioLiP]