Structure of PDB 8gk8 Chain A

Receptor sequence
>8gk8A (length=1041) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
QIKKLLVANRGEIAIRIFAAAAELDISTVAIYSNEDKSSLHRYKADESYL
VGSDLGPAESYLNIERIIDVAKQANVDAIHPGYGFLSENEQFARRCAEEG
IKFIGPHLEHLDMFGDKVKARTTAIKADLPVIPGTDGPIKSYELAKEFAE
EAGFPLMIKAIVREESELEDAFHRAKSEAEKVYIERYIDNPKHIEVQVIG
DEHGNIVHLFERDCSVQRRHQKVVEVAPSVGLSPTLRQRICDAAIQLMEN
IKYVNAGTVEFLVSGDEFFFIEVNPRVQVEHTITEMVTGIDIVKTQILVA
AGADLFGEEINMPQQKDITTLGYAIQCRITTEDPLNDFMPDTGTIIAYRS
SGGFGVRLDAGDGFQGAEISPYYDSLLVKLSTHAISFKQAEEKMVRSLRE
MRIRGVKTNIPFLINVMKNKKFTSGDYTTKFIEETPELFDIQPSLDRGTK
TLEYIGNVTINGFPNVEKRPKPDYELASIPTVSSSKIASFSGTKQLLDEV
GPKGVAEWVKKQDDVLLTDTTFRDAHQSLLATRVRTKDMINIASKTADVF
KDGFSLEMWGGATFDVAYNFLKENPWERLERLRKAIPNVLFQMLLRASNA
VGYKNYPDNVIHKFVQESAKAGIDVFRIFDSLNWVDQMKVANEAVQEAGK
ISEGTICYTGDILNPERSNIYTLEYYVKLAKELEREGFHILAIKDMAGLL
KPKAAYELIGELKSAVDLPIHLHTHDTSGNGLLTYKQAIDAGVDIIDTAV
ASMSGLTSQPSANSLYYALNGFPRHLRTDIEGMESLSHYWSTVRTYYSDF
ESDIKSPNTEIYQHEMPGGQYSNLSQQAKSLGLGERFDEVKDMYRRVNFL
FGDIVKVTPSSKVVGDMALYMVQNDLDEQSVITDGPESVVSFFKGEIGQP
VNGFNKDLQAVILKGQEALTARPGEYLEPVDFEKVRELLEEEQQGPVTEQ
DIISYVLYPKVYEQYIQTRNQYGNLSLLDTPTFFFGMRNGETVEIEIDKG
KRLIIKLETISEPDENGNRTIYYAMNGQARRIYIKDEMKME
3D structure
PDB8gk8 R21A Staphylococcus aureus pyruvate carboxylase
ChainA
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.1: pyruvate carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A R44 Y45 A47 D48 E49 S50 R42 Y43 A45 D46 E47 S48
BS02 BTI A N475 G480 F481 P482 F588 K590 N457 G462 F463 P464 F570 K572
BS03 ACO A E418 R420 R422 L463 R465 N1049 R1053 E400 R402 R404 L445 R447 N1026 R1030
BS04 MN A D542 K712 H741 H743 D524 K694 H723 H725
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004736 pyruvate carboxylase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gk8, PDBe:8gk8, PDBj:8gk8
PDBsum8gk8
PubMed37603581
UniProtA0A3A5LTU8

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