Structure of PDB 8gk3 Chain A

Receptor sequence
>8gk3A (length=473) Species: 9606 (Homo sapiens) [Search protein sequence]
YGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYGKVWGI
YDGQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDE
EWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKH
VFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIK
VFPFLTPILEALNITVFPREVISFLTKSVKQIKEGRLKETQKHRVDFLQL
MIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH
PDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLE
RVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSAANA
DNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIP
LKLRFGGLLLTEKPIVLKAESRD
3D structure
PDB8gk3 Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate.
ChainA
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A R105 I118 S119 R130 A305 G306 T309 L373 R375 F435 R440 N441 C442 I443 A448 M452 R81 I94 S95 R106 A281 G282 T285 L349 R351 F411 R416 N417 C418 I419 A424 M428
BS02 ZWY A Y25 F226 F228 Y1 F202 F204
BS03 ZWY A L236 R243 L212 R219
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0050649 testosterone 6-beta-hydroxylase activity
GO:0062183 all-trans retinoic acid 18-hydroxylase activity
GO:0070330 aromatase activity
GO:0101020 estrogen 16-alpha-hydroxylase activity
GO:0101021 estrogen 2-hydroxylase activity
Biological Process
GO:0002933 lipid hydroxylation
GO:0006694 steroid biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0070989 oxidative demethylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8gk3, PDBe:8gk3, PDBj:8gk3
PDBsum8gk3
PubMed37392852
UniProtP24462|CP3A7_HUMAN Cytochrome P450 3A7 (Gene Name=CYP3A7)

[Back to BioLiP]